By Eon Nigel Harris MD, DM, Silvia S. Pierangeli PhD (auth.), Doruk Erkan, Silvia S. Pierangeli (eds.)
The overseas Congress on Antiphospholipid Antibodies is held each 3 years to debate the new advances and destiny instructions in Antiphospholipid Syndrome (APS). This quantity collects the clinical highlights and new findings approximately APS that have been generated from the latest thirteenth Congress, held in Galveston, Texas in 2010. Chapters have been written through an internationally-distinguished team of scientists from the point-of-view of a number of strong point components. every one bankruptcy used to be written in a uniform and systematic foundation to give the newest evidence-based learn, together with the fundamental technology of APS, job strength studies from the Congress on debatable points of APS, and destiny instructions of APS examine. This e-book will attract all clinicians interested in the therapy and administration of APS sufferers, to citizens in numerous scientific subspecialties, and to analyze scientists drawn to a greater knowing of this advanced and evolving sickness.
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Extra resources for Antiphospholipid Syndrome: Insights and Highlights from the 13th International Congress on Antiphospholipid Antibodies
Lupus. 2004;13:17–23. 82. Blank M, Krause I, Fridkin M, et al. Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome. J Clin Invest. 2002; 109: 797–804. 83. Pierangeli SS, Blank M, Liu X, et al. A peptide that shares similarity with bacterial antigens reverses thrombogenic properties of antiphospholipid antibodies in vivo. J Autoimmun. 2004;22:217–25. 84. Harris EN, Gharavi AE, Boey ML, et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus.
Brenner B, Vulfsons SL, Lanir N, Nahir M. Coexistence of familial antiphospholipid syndrome and factor V Leiden: impact on thrombotic diathesis. Br J Haematol. 1996;94: 166–7. 56. Chopra N, Koren S, Greer WL, et al. Factor V Leiden, prothrombin gene mutation, and thrombosis risk in patients with antiphospholipid antibodies. J Rheumatol. 2002;29:1683–8. 57. Bentolila S, Ripoll L, Drouet L, Crassard I, Tournier-Lasserve E, Piette JC. Lack of association between thrombosis in primary antiphospholipid syndrome and the recently described thrombophilic 3¢-untranslated prothrombin gene polymorphism.
Pierangeli’s laboratory indicate a role of TLR7 and TLR9 in the production of thrombogenic aPL in mice . Future Research Directions Antiphospholipid Syndrome is a multisystemic and heterogeneous disease with devastating consequences in affected individuals. New treatments are urgently needed that may hopefully provide an alternative approach to long-term anticoagulation and general immunosuppression. The current recommended anticoagulant and immunosuppressive treatments for aPL-related clinical manifestations are associated with significant side effects.